The problems facing the health industry are too complex for any one organization to solve alone. Improving health outcomes, access and affordability requires collaboration and coordination from diverse sectors, including life sciences, healthcare providers, payers, public health and services, and community resources. Developing the innovative partnerships and the leadership necessary to address issues like where to invest in R&D, how to implement technology solutions, pathways for clinical treatments, best practices in data sharing, etc is crucial for success. This presentation focuses on the opportunity pharmaceutical leaders have in leading the future health ecosystem by building collaborative partnerships that have the capacity to add tremendous value to promoting health and wellness throughout the globe. We offer strategies for building and demonstrating health ecosystem leadership through case studies and practical learning applications that leaders can implement back on the job, with their teams and their organizations.